Modular Access to Diverse Chemiluminescent Dioxetane‐Luminophores through Convergent Synthesis

Abstract Adamantyl‐dioxetane luminophores are an important class of chemiluminescent molecular probes for diagnostics and imaging. We have developed a new efficient synthetic route preparation adamantyl‐enolether as precursors dioxetane luminophores. The synthesis is convergent, using unusual Stille cross‐coupling reaction employing stannane‐enolether, to directly afford adamantyl‐enolether. In following simple step, the obtained by oxidation enolether precursor with singlet‐oxygen. scope this broad since large number haloaryl substrates either commercially available or easily accessible. Such late‐stage derivatization strategy simplifies rapid exploration novel luminogenic structures in library format known expect that will be particularly useful design yet unexplored